The Abbey, whose origin is related to the arrival in the area of Benedictine monks around the 18th century, experienced its era of maximum splendour towards the end of the 9th century, when the Lombard Queen Ageltrude provided a new impulse for the Abbey by founding a church on the site of a pagan temple dedicated to the goddess Bona, from whom Rambona derives its name. After a long period of prosperity, it was sacked and partially destroyed by Francesco Sforza in 1433 and from then onwards began its period of decline. From 1483 to 1821 it was administered by laymen and subsequently became private property, retaining, however, its parish functions from 1819. Over the course of time the monastic structure underwent numerous refurbishments, including work which re-used architectural and decorative materials from the Roman period dating back to the 11th and 12th centuries. Of particular interest is the crypt designed with a nave and four aisles divided by Roman columns with Romanesque capitals.

The Abbey is currently closed because of the earthquake occurred in August 2016.