San Domenico’s church was built at the beginning of the XIII century, according to tradition founded from San Domenico shortly before his death. From the original structure of thirteenth century remains very little having suffered over the centuries amendments and adjustments. In 1500, in particular, the church was the subject of numerous interventions that modified according to the new architectural taste, outside was erected a new bell tower but was the inside to be modified in a substantial manner.

But the most important and significant modification was the positioning of the big paint “Madonna del Rosario e Santi” of Lorenzo Lotto, finished by the venetian painter in the spring of 1539. The “Madonna del Rosario” in Cingoli dates back to the second sojourn of Lorenzo Lotto in The Marches. This work was commissioned by the local “Confraternita del Rosario”, a brotherhood residing in the Church of San Domenico. The painting is signed L. LOTVS and bears the date 1539 in Roman numbers. This work (389x265 cm) is considered one of Lotto’s masterpieces. Reading the painting from top to bottom and from left to right, you can see: the five Joyful Mysteries (the Annunciation of the Lord to Mary; the Visitation of Mary to Elizabeth; the Nativity; the Presentation of Jesus in the Temple; the Finding in the Temple), the five Sorrowful Mysteries (the Agony of Jesus in the Garden; the Scourging at the Pillar; the Crowning with Thorns; the Carrying of the Cross; the Crucifixion), and the five Glorious Mysteries (the Resurrection of Jesus; the Ascension into Heaven; the Descent of the Holy Spirit; the Assumption of Mary into Heaven; the Coronation of Mary).

Due to the earthquake occurred in 2016, the church is temporarily closed.