The advent of Friars Minor in S. Colomba, dependent on the Abbey of Pubblica (Piobblico) in Sarnano, dates back to the early '300.

In the first half of the fourteenth century the old settlement underwent a major restoration, so that it constituted a new building. This is attested by a rescript of the Bishop of Fermo Giacomo who, in 1338, granted an indulgence of forty days to anyone who would visit the Church and help it. Later, around 1360, the Franciscans accepted the invitation of the parish priest of the Church of S. Gregorio to move inside the castle of Mogliano and to build a new convent adjoining it. According to local historians, the monastery of S. Colomba was demolished to rebuild, with the remaining material, the new one. The Church however remained open for worship.
The Church of S. Colomba di Mogliano has an impressive panelled ceiling painted by G. B. Fagiani, from Mogliano, between 1750 and 1752. Behind the altar, a valuable painting by Durante Nobili, one of Lotto's pupils: Madonna and Child Enthroned with the Saints Giuseppe, Colomba, Giovanni Battista, Francesco from Assisi and Benedetto (1554). Of great beauty the cloister, dating back to the beginning of the eighteenth century with its frescoed lunettes and wood furnishings.