In the spring of 1537, the Dominican Friars from Cingoli commissioned Lotto to paint a picture for the high altar of their renovated Church. This painting, devoted to the subject of the Lady of the Rosary, was completed by Lotto in 1539, as we can read on the majestic stone on which Mary’s throne lies. This impressive picture, 389×264 cm, is undoubtedly one of Lotto’s “masterpieces”: when he painted it, he was sixty years old by then and he confirmed his stylistic, technical, cultural and spiritual competence; indeed the Madonna of the Rosary in Cingoli is one of the most elaborate and semantically deep paintings of the sensitive and erudite Venetian artist.

On an almost nocturnal sky, a majestic rose garden stands out; in the background is a wood trellis on which there are fifteen medallions arranged in three different levels forming a sort of pyramid. These medallions represent the subjects of the fifteen mysteries of the Virgin cult of the Rosary. Detailed masterpieces in the masterpiece.
A limitless wall blocks the bottom of the big rose garden. This wall is made of large blocks and it has been eroded over time; it is another background to the holy conversation with the Virgin, who is on the throne with Jesus. She is surrounded by Saints who are honouring her. They are arranged in three different levels: on the first level there is Saint Dominic and Saint Esuperanzio (patron saint of Cingoli); on the second level there is Maria Magdalene, in a smart dress of the 16th Century and Catherine of Siena; on the last level there are the Dominican Saints Vincent Ferrer and the unmistakable Peter of Verona.