Raphael’s native house was built in the 14th century. Raffaello’s father, Giovanni Santi (1435 - 1494) purchased it in 1460.
Giovanni Santi himself was a humanist, poet and painter at the court of Federico da Montefeltro, where Raphael (1483-1520), still very young, started to learn the first concepts of painting.
Since then the house was purchased in 1635 by Muzio Oddi, an architect from Urbino, and then, in 1873, it became property of the Accademia Raffaello (Raphael Academy), founded in 1869 by Pompeo Gherardi, who since then promoted any kind of study and initiative dedicated to the painter. 
On the first floor, we find a large room with coffered ceiling, where the work by Giovanni Santi, the Annunciation, is displayed together with the copies of "Madonna of the chair" and "Ezechiele’s vision". 

Noteworthy is the "Madonna with the Child", located in the room where we suppose the painter was born, a work that the critics attributed sometimes to Giovanni Santi and sometimes to young Raphael. There are as well a drawing by Bramante (1444 - 1514) and a collection of Renaissance ceramics. On the upper floor, where the Academy is based, you can see manuscripts, rare editions, coins and portraits dating back to the 19th century.