The Church of San Francesco, built by the Franciscan Brotherhood in the second half of the 1200s and later remodeled in the late Baroque style, has an 18th-century wooden choir, four stucco statues of the Theological Virtues made in 1752, and an organ from 1753. The high altar once had a splendid Madonna of the Milk by Antonio da Faenza (1525), now inside the Collegiate Church, in which there is also the Addolorata Chapel, repainted by Cesare Peruzzi between 1934 and 1941. The Mary Immaculate by the Flemish painter Ernest Van Schayck (1631) is pervaded with devotional touches supported by a careful reading of Bolognese classicism.

The church is currently closed because of the earthquake occurred in August 2016.