It was first built in ancient times and it was rebuilt in the 16th and 17th century as it was considered too small in comparison to the other churches of the town. Outside you can see the brick façade which dominates the square of the Palazzo della Ragione and it’s divided into three parts by small columns. Over the portal, right at the centre, you can see the coat- of- arm of Pope Clement XIV, who was born in the town and who became pope from 1769 to 1774.

In 1639 the parish church became a basilica due to Pope Urban VIII who turned San’Angelo in Vado into a Town and Diocese. The church has a single nave and it was badly damaged starting from 1728. Works were carried out with the properties of the church and the donations of the faithful and of the confraternities.

The new cathedral was consecrated in 1770, inside there are a naive and two aisles and two chapels at the sides, one of which is dedicated to the Crying Madonna and the second one to the Ortolani confraternity. Inside you can see paintings by Francesco Mancini, Schiroli, other paintings attribute to Gentile da Fabriano (14th century) , Claudio Ridolfi (1570-1644) and Guido Reni (1575-1642): in the chapel of the Crying Madonna (1855) you can find works by local craftsmen: a wooden choir by Benedetto Boccioni and a wrought iron fence.