Built by the architect Salino Lombardo for the friars of the town and modernized at the end of the 1700s in Baroque style, inside it preserves numerous altarpieces including the Immaculate Conception, the Crucifixion attributed to Guido Reni, works by the Pennese painter Antonio Liozzi and the wooden statue in Baroque style, by the sculptor Antonio Molino, of the Madonna of the Rosary Saints, to whom the Confraternity is entrusted and venerated. The church also boasts a splendid wooden choir and an 18th century organ. In the restored urn are exhibited the relics of Blessed John of Penna, spiritual son and companion of St. Francis, mentioned in the '' Fioretti ''