The Monastery of St. Clare is the former monastery of the Poor Clares of Urbino. It is one of the best examples of Renaissance architecture. It currently houses the Higher Institute for Artistic Industries of Urbino (ISIA). It was built in 1420 to house the Conservatory of the widows; in 1456 it underwent the rule of observance of Saint Clare by Pope Callistus III, thanks to the Duke Federico da Montefeltro III.  The convent church was changed in the sixteenth and seventeenth century under the Della Rovere family; in 1538 it  became the Ducal Mausoleum : here the Duke Francesco Maria I della Rovere, his wife Eleonora Gonzaga, his son Cardinal Giulio della Rovere, his daughter-in-law Giulia Varano and his granddaughter Eleanor or Lavinia Della Rovere were buried. In 1864 the building was confiscated by the Municipality and became an Institute for female education until 1904. After this year an hospital was established there. In the seventies the hospital was placed in an area outside Urbino, so the former monastery became the seat of the Higher Institute for Artistic Industries (ISIA).