Starting with the Romans, many societies have enjoyed the benefits of the thermal waters found in the Marche. In more recent times Spa centres have become synonymous with tourism, and the distinction between centres for health and specialised medical care, wellness centres and beauty farms tends to be much less well defined. With regard to the chemical-physical classification of the waters, the mineral springs in the Marche are sulphurous and are used for mineral water cures, beauty treatments as well as for bottling. They are recommended not only for the benefits they bring to digestive, ear-nose-and-throat, respiratory, skin, gynaecological, arthrorheumatic, vascular and renal conditions, but also for problems with the skin and aesthetic cures. Furthermore, in response to the new trends in tourist demand and to increase the attraction of the existing spa centre facilities, the Region actively promotes Spa tourism which is an undeniable resource in addition to the traditional naturalist, historic-cultural and enogastronomic tourism. This itinerary will take us through the Spa centres in the Marche giving a description of the Spa resorts and of the mineral water springs in the region, ranging from those already known nationally to those which, although somewhat lesser known in the territory, are very worthy of being brought to the attention of travellers.