The Annunciation, now preserved in the church of S. Maria Nuova in Fano, is an oil on panel (size212 x 172 cm) which was made by the Perugino between 1488 and 1490 for the Order of Franciscans of Fano. The work depicts the Angel of the Lord who, holding the white lily, symbol of purity, gives the announcement to the Virgin, quietly surprised while reading a book.
The scene takes place according to a composed and pleasant framework within an architectural structure of pillars and vaults that directs the viewer's gaze toward the open hilly landscape in the background; in the upper part is the God Father who, into a bright halo surrounded by cherubs, blesses the advent of Christ and sends the dove of the Holy Spirit.